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Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
Acromegaly - Diagnosis ... : • Classic Acromegaly ... Differential Diagnosis ... resistance pseudo-acromegaly ... thakre_anuj) #Acromegaly
Tall Stature - Differential Diagnosis Algorithm

Normal Growth (BA=CA)
 • Familial Tall Stature
 • XYY Syndrome
Obese BMI
Tall Stature - Differential ... Puberty Onset • GH ... Resistance • Acromegaly ... #TallStature #Differential
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
clinical findings • Acromegaly ... GH excess prior ... GH excess after ... plate fusion -> acromegaly ... rare causes of acromegaly
Acromegaly 
Caused by over-secretion of growth hormone (GH) from the pituitary gland. 
The condition is rare
Acromegaly Caused ... growth hormone (GH ... #Acromegaly #Signs
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... /Symptoms: • GH ... abn lipid • GH ... - Giantism or acromegaly ... GrowthHormone #GH
Hirsutism - Differential Diagnosis
Defined as excessive dark, coarse, male-pattern hair growth
Hirsutism causes in premenopausal women:
 •
Hirsutism - Differential ... Cushing's Syndrome, Acromegaly ... Cushing's Syndrome, Acromegaly ... mendesthiagob #Hirsutism #Differential
Sellar / Pituitary Mass - Differential Diagnosis Algorithm
Adenoma - Primary Anterior Pituitary
 - Secreting
Pituitary Mass - Differential ... Prolactin • GH ... SellarMass #Pituitary #Differential
Multiple Endocrine Neoplasias (MEN syndromes) 

MEN I
• Hyperparathyroidism 
• Hypercalcemia 
• Possible ZE syndrome 
• Various
Pituitary path • Acromegaly ... MultipleEndocrineNeoplasia #Differential
#ACROMEGALY #management #algorithm #treatment
#ACROMEGALY #management
Hyperphosphatemia - Differential Diagnosis Algorithm
Transcellular Shift:
 • Rhabdomyolysis
 • Tumor Lysis
 • Metabolic or Respiratory Acidosis
Hyperphosphatemia - Differential ... Pseudo-hypoparathyroidism • Acromegaly ... HighPhosphate #Differential