317 results
Acromegaly 
Caused by over-secretion of growth hormone (GH) from the pituitary gland. 
The condition is rare
Acromegaly Caused ... growth hormone (GH ... #Acromegaly #Signs ... Symptoms #Diagnosis #Endocrinology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
Acromegaly - Diagnosis ... : • Classic Acromegaly ... resistance pseudo-acromegaly ... thakre_anuj) #Acromegaly ... Diagnosis #Management #Endocrinology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
clinical findings • Acromegaly ... GH excess prior ... plate fusion -> acromegaly ... rare causes of acromegaly ... signs #symptoms #endocrinology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... /Symptoms: • GH ... abn lipid • GH ... - Giantism or acromegaly ... #FeedbackLoop #endocrinology
Acromegaly Testing Algorithm
INDICATIONS FOR TESTING:
 • Adults – enlarged facial or acral features, abnormal musculoskeletal growth
Acromegaly Testing ... Growth Hormone (GH ... ARUPConsult @ARUPLabs #Acromegaly ... Algorithm #diagnosis #endocrinology
Tall Stature - Differential Diagnosis Algorithm

Normal Growth (BA=CA)
 • Familial Tall Stature
 • XYY Syndrome
Obese BMI
Puberty Onset • GH ... Resistance • Acromegaly ... Diagnosis #Algorithm #endocrinology
Multiple Endocrine Neoplasias (MEN syndromes) 

MEN I
• Hyperparathyroidism 
• Hypercalcemia 
• Possible ZE syndrome 
• Various
Pituitary path • Acromegaly ... #Differential #Endocrinology
Hirsutism - Differential Diagnosis
Defined as excessive dark, coarse, male-pattern hair growth
Hirsutism causes in premenopausal women:
 •
Cushing's Syndrome, Acromegaly ... Cushing's Syndrome, Acromegaly ... Differential #Diagnosis #endocrinology
Sellar / Pituitary Mass - Differential Diagnosis Algorithm
Adenoma - Primary Anterior Pituitary
 - Secreting
Prolactin • GH ... Diagnosis #Algorithm #endocrinology
Hyperphosphatemia - Differential Diagnosis Algorithm
Transcellular Shift:
 • Rhabdomyolysis
 • Tumor Lysis
 • Metabolic or Respiratory Acidosis
Pseudo-hypoparathyroidism • Acromegaly ... Diagnosis #Algorithm #endocrinology