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differential causes transaminitis ascites injury abnormal albumin gradient nephrology aclf acute chemistry chronic elevated enzymes gastroenterology hepatocellular hepatomegaly hepatorenal hrs
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... cirrhosis, Portal ... #Injury #hepatology ... #LFTs #transaminitis ... #differential #diagnosis
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Non-Malignant • Fatty Liver ... • Right Heart Failure ... Inflammatory • Alcoholic ... Primary Biliary Cirrhosis ... #Hepatology
Diagnosis of ascites according to the serum ascites albumin gradient (SAAG) SAAG ≥ 1.1: - Ascitic protein
protein ≤ 2.5 g/dL: Cirrhosis ... syndrome, Massive liver ... 2.5 g/dL: Heart failure ... albumin #gradient #hepatology ... #algorithm
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Infections Alcohol-Associated ... Hepatitis (AAH) ... #Failure #Cirrhosis ... #Hepatology #gastroenterology ... #management #diagnosis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... hepatitis • Drugs ... Infiltrative • Cirrhosis ... • Others #LFTs ... #Hepatology #LiverEnzymes
Causes of Ascites Normal Peritoneum Portal hypertension (SAAG > 1.1 g/dL) 1. Hepatic congestionl
- Heart failure ... - Cirrhosis ... - Alcoholic hepatitis ... Ascites #Causes #diagnosis ... #differential #hepatology
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Sarcoidosis Toxic - Alcohol ... Nonalcoholic fatty liver ... Congestive heart failure ... 14 percent) #Diagnosis ... #Differential #Hepatology
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 Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
failure 1) Hepatocellular ... Drugs (MDMA), Alcohol ... #hepatology #algorithm ... Transaminitis #LFTs ... #hepatitis
Serum Ascites Albumin Gradient (SAAG) - Differential Diagnosis High albumin gradient (>1.1 g/dl): - Cirrhosis - Alcoholic
Albumin Gradient (SAAG ... - Differential Diagnosis ... - Alcoholic hepatitis ... Fulminant hepatic failure ... #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... - Differential Diagnosis ... Congenital, Others, Cirrhosis ... Burak @kwburak #LFTs ... #diagnosis #hepatology
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