11 results
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Antinuclear Antibody ... • Reticular/AMA ... PBC/SjS OS - AMA ... ARUPConsult @ARUPLabs #ANA ... #Antinuclear #Antibody
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antibody refers ... 33% of healthy adults ... context of other symptoms ... : The ANA patterns ... #patterns #rheumatology
Antinuclear Antibody Testing Cytoplasmic Patterns
Reticular/AMA: 
 • PBC, SSc, PBC/SSc OS, PBC/SjS OS
 • AMA
Speckled:
 •
Antinuclear Antibody ... Reticular/AMA: ... PBC/SjS OS • AMA ... ARUPConsult @ARUPLabs #ANA ... #Antinuclear #Antibody
Antinuclear Antibody Testing - Nuclear Patterns
Homogeneous pattern: 
 • SLE, SSc, AIH, JIA
 • dsDNA, chromatin,
Antinuclear Antibody ... ARUPConsult @ARUPLabs #ANA ... #Antinuclear #Antibody ... #differential #diagnosis ... #rheumatology
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
antibody, Anti-GBM ... antibody • Urine ... or serologies + symptoms ... • IF staining patterns ... #management #treatment
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... the chest/trunk Symptoms ... ANA Labs: • ↑ESR ... #rheumatology # ... management
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
< 30 years - Aorta ... • GCA: - Aorta ... Presentation - Systemic Symptoms ... LFT • ESR • ANA ... #rheumatology #
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Epidemiology: • Young adults ... meningitis), MCC CNS symptoms ... Glucocorticoids 5-ASA ... #management #signs ... #symptoms #rheumatology
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
vasculitis in older adults ... those coming off aorta ... them, but urgent rheumatology ... Temporal #Signs #Symptoms ... #Diagnosis #Management
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
cancer-associated adult ... • Anti-NXP2 (ANA ... -1 antibodies (ANA ... pattern of muscle ... or head drop • ANA