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differential testing cytoplasmic nuclear adult antibodies classification disease onset polychondritis prs pulmonary relapsing renal stills syndromes treatment vasculitides vasculitis
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... • Reticular/AMA ... PBC/SjS OS - AMA ... ARUPConsult @ARUPLabs #ANA ... #Antinuclear #Antibody
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antibody refers ... context of other symptoms ... : The ANA patterns ... #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
Antinuclear Antibody ... Reticular/AMA: ... PBC/SjS OS • AMA ... ARUPConsult @ARUPLabs #ANA ... #Antinuclear #Antibody
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Antinuclear Antibody ... ARUPConsult @ARUPLabs #ANA ... #Antinuclear #Antibody ... #differential #diagnosis ... #rheumatology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
antibody, Anti-GBM ... antibody • Urine ... or serologies + symptoms ... • IF staining patterns ... #management #treatment
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
the chest/trunk Symptoms ... ANA Labs: • ↑ESR ... Stills #disease #AOSD ... #diagnosis #rheumatology ... #management
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
< 30 years - Aorta ... • GCA: - Aorta ... Presentation - Systemic Symptoms ... LFT • ESR • ANA ... #rheumatology #
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
ethnicities Symptoms ... Large vessels (aorta ... Nonspecific ↑ ESR, CRP, ANA ... Polychondritis #rheumatology ... #diagnosis #management
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