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ana erythematosus lupus antibodies patterns sle autoimmune bleeding bruising causes classification disease hematology igg4 management mimickers myopathy myositis phenotypes related
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... Kumfer @AnnKumfer #Antinuclear ... #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... • Homogeneous: Systemic ... Kumfer @AnnKumfer #Antinuclear ... #patterns #rheumatology ... #diagnosis #differential
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... #autoantibodies ... erythematosus #diagnosis ... #rheumatology #
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
Retroperitoneum and aorta ... female, asian • Systemic ... serum lgE, no autoantibodies ... (antinuclear antibodies ... workup #treatment #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Auto-Antibodies: - ANA ... (aPL) 30-45% Differential ... #autoantibodies ... #rheumatology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Diagnosis Algorithm ... ASA) • Renal Disease ... Vascular System ... #Diagnosis #Algorithm ... #Causes #Hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
< 30 years - Aorta ... branches • GCA: - Aorta ... Diagnosis: Systemic ... LFT • ESR • ANA ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Anti-Ro/SSA autoantibodies ... permanent alopecia Differential ... Diagnosis: • ANCA-associated ... Non-autoimmune rheumatologic ... #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... RP-ILD), dermato-rheumatologic ... Mechanic's hands Autoantibodies ... • Conduction system ... #differential #
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