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management sle differential erythematosus hematology systemic druginduced summary causes cell classification comparison dil disease gap globulin hypertension igg4 indications nephritis
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
pancreas, biliary, renal ... orientation): ... lesions, meninges, kidneys ... management #phenotypes #workup ... #treatment #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... • Immunologic Workup ... life-threatening • Treatment ... Erythematosus #Diagnosis ... Management #Summary #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
myalgia, serositis, Kidney ... • Immunologic Workup ... • Immunologic Workup ... comparison #table #rheumatology ... #diagnosis #management
Management of Lupus Nephritis Lupus nephritis (LN) in 10 to 40% of SLE Hallmark = proteinuria 20.5 g/g
Nephritis Lupus ... or 0.5 g/day → renal ... histological evaluation ... Nephritis #Management #treatment ... #management #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... severe disease & renal ... severe disease Treatment ... #SLE #Summary #diagnosis ... #rheumatology #
Causes of Secondary Hypertension - Workup and Differential Diagnosis Approach (when evaluation should be done): 1. Severe or
Approach (when evaluation ... disturbance, or acute kidney ... eg, presence of renal ... • Vascular: Renal ... Renal parenchymal
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... APLA/LAC: • Renal ... C4) • ds-DNA: Kidney ... induced SLE • Kidney ... #Rheumatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory Evaluation ... activity is the diagnostic ... available for rapid diagnosis ... the presence of renal ... #Workup #Hematology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
myalgia, serositis, Kidney ... • Immunologic Workup ... cutaneous-DIL • Evolution ... #DIL #rheumatology ... #diagnosis #treatment
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pulmonary and renal ... inflammation Others: • Lupus ... such as systemic lupus ... • Urinalysis (Renal ... #rheumatology #
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