1970 results
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Peripheral Blood Smear ... Megaloblastic Anemia ... Autoimmune hemolytic anemia ... cells: Sickle cell disease ... Peripheral #Blood #Smear
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... Normochromic RBCs on Smear ... • Anemia of Chronic ... Disease • Marrow ... Spherocytes on Smear
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... Peripheral blood smear ... → Sickle Cell anemia ... malignancy, autoimmune disease ... Microangiopathic hemolytic anemia
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Causes of Anemia ... Normal Blood Smear ... • Pernicious Anemia ... • Pancreatic Disease ... • Liver Disease
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
, Drugs, Liver Disease ... Defects: Sickle cell anemia ... Electrolytes: Wilson's disease ... Peripheral Blood Smear
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
peripheral blood smear ... PT, aPTT(liver disease ... changes), high MCV anemia ... bypass), LFT (liver disease ... dysplasia on the smear
Sickle cells
These photos show sickle cells on peripheral blood smears. In the left photo target cells
peripheral blood smears ... to sickle cell disease ... no significant anemia ... thalassemia, and HbSC disease ... BloodSmear #Blood #Smear
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Disease ... • Symptoms of anemia ... • hemolytic anemia ... IgM) • Blood smear ... #hemolytic #anemia
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Peripheral Smear ... hemolysis, deficiency anemia ... Vasculitides, IBD, Celiac disease
Oroya Fever
Hematologic disease caused by Bartonella bacilliformis
Restricted to the Andes highlands of Peru & Ecuador
B. bacilliformis:
Fever Hematologic disease ... severe hemolytic anemia ... phase: Peripheral smear