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Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... disease, hereditary angioedema ... Hypocomplementemia #Low #Complement
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Selected Diseases on Complement ... • Hereditary angiooedema ... ThePeanutKidney #Complement
Tranexamic Acid - Indications and Pharmacology Pharmacokinetics: • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
fibrinolysis (reduces complement ... w/ hereditary angioedema ... : Urine Common Uses ... rapid injection; Nausea
Quincke's Disease - Isolated Uvula Angioedema By Dr. Ajay Jain #Quinckes #Disease #Edema #Uvula #Uvulitis #Angioedema #uvular #clinical
Isolated Uvula Angioedema ... Uvula #Uvulitis #Angioedema ... uvular #clinical #video
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 Angioedema - Classification Diagnosis and Treatment Types of Angioedema: • Acute allergic angioedema - Usually occurs with
Angioedema - Classification ... Treatment Types of Angioedema ... Acute allergic angioedema ... • Idiopathic angioedema ... cell-mediated in > 90% of cases
Causes of Hemolytic Anemia - Differential Diagnosis Inherited • Membrane • Internal - Hemoglobin
Causes of Hemolytic ... Antibody/DAT+ - Complement ... Differential #Diagnosis #Causes
Facial Swelling from Hereditary Angioedema on Physical Examination 19 year old Hereditary Angioedema (HAE) patient from Turkey.
from Hereditary Angioedema ... old Hereditary Angioedema ... HAE #Hereditary #Angioedema ... #clinical #video
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 Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
dysmorphic RBC, RBC casts ... staining (lg + complement ... MGPN • Complement ... of alternative complement ... MPGN without complement
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... staining): • Low Complement ... Idiopathic • Normal Complement
Complement 1 esterase inhibitor (C1-INH) Deficiency Testing Algorithm INDICATIONS FOR TESTING: • Recurrent angioedema (without urticaria) •
Complement 1 esterase ... : • Recurrent angioedema ... family history for angioedema ... ARUPLabs #C1INH #Complement
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