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Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
Excretion Carbonic Anhydrase ... irrigation • Management ... +2Cl- Symport (Loop ... Kidney stones caused
Diuretic Electrolyte Excretion Effects Diuresis, Na+, K+, Mg2+, Ca2+, Cl-, HCO3-, Uric Acid - Thiazide Type
Thiazide Type - Loop ... Blocker - Carbonic Anhydrase
Diuretics sites of action on the nephron 1) Acetazolamide (carbonic anhydrase inhibitor) 2) Osmotic diuretics (e.g. mannitol) 3) Loop
Acetazolamide (carbonic anhydrase ... . mannitol) 3) Loop
Overview of effects of diuretics and hormones involved in fluid homeostasis. #diruetic #diuretics #aldosterone #ADH #ANP #BNP #thiazide
hydrocholorothyazide #loop ... amiloride #carbonic #anhydrase
Summary of Diuretic Agents Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction CARBONIC ANHYDRASE
Interaction CARBONIC ANHYDRASE ... empagliflozin LOOP
Thiazide diuretics Carbonic anhydrase inhibitors (e.g., acetazolamide) Nat-Cl symport Na and HCO;- reabsorption Aldosterone antagonists (e.g., spironolactone) Nat channel (indirect effect) Loop diuretics (e.g., furosemide) Amiloride, #triamterene Nat-K+-2CF symport Na channel (direct effect) #NaCI reabsorption
diuretics Carbonic anhydrase ... indirect effect) Loop
Diuretics - Pharmacology Thiazides diuretics: • Inhibit Na+ Cl- cotransporter in distal tubule • Chlorothiazide, Chlorthalidone, Indapamide,
Metolazone Loop ... Triamterene Carbonic anhydrase ... nephrology #conversion #loop ... #thiazide #classes
Pharmacology of diuretics Acetazolamide, Loop diuretics, Thiazide‐like diuretics, MRA, Amiloride Site of Action, Maximum Dose, Half-Life, Onset, Bioavailability,
Acetazolamide, Loop ... HalfLife #Dosing #Loop ... CHF #Cardiology #Management
Management of SIADH Treat underlying cause: • Causes can include pain, primary lung pathology, post-operative phenomenon, medications,
Management of SIADH ... Treat underlying cause ... : • Causes can ... ascending limb of the loop ... SatyaPatelMD #SIADH #Management
Medications for High-Altitude Sickness Acetazolarnide • Carbonic Anydrase Inhibitor Bicarb diuresis & metabolic Acidosis ->
• Carbonic Anydrase ... #Medications #Management
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