298 results
Diuretic Electrolyte Excretion Effects 
Diuresis, Na+, K+, Mg2+, Ca2+, Cl-, HCO3-, Uric Acid
 - Thiazide Type
Diuretic Electrolyte ... Excretion Effects Diuresis ... - Aldosterone Antagonist ... Anhydrase Inhibitor #diuretics
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Pathophysiology - Diuretic ... Sites of Action Diuretics ... 5) Aldosterone antagonists ... 6) ADH antagonists ... Pathophysiology #Diuretics
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
Summary of Diuretic ... empagliflozin LOOP DIURETICS ... POTASSIUM-SPARING DIURETICS ... VASOPRESSIN (ADH) ANTAGONISTS ... Tolvaptan #Diuretics
HFrEF: Guideline Directed Medical Therapy

"Must Be On"
 • ACEI, ARB, or ARNI AND select Beta Blockers
Can Be On" • Diuretics ... • Aldosterone antagonist ... • Aldosterone antagonist ... Reducing: • Diuretics ... metolazone in diuretic
Ascites Management Principles
Low Salt Diet - 2000 Mg Sodium
Fluid Restriction - Never
Work-horse Diuretic - Aldosterone Antagonist
Combination
Never Work-horse Diuretic ... - Aldosterone Antagonist ... Combination Diuretics ... - Add-on Loop Diuretics
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
Diuretics and Agents ... Symport (Loop Diuretics ... Mineralocorticoid Receptor Antagonists ... (Aldosterone Antagonists ... Vasopressin Receptor Antagonists
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... Thiazides diuretics ... Metolazone Loop diuretics ... Potassium sparing diuretics ... Vasopressin receptor antagonists
Thiazide
diuretics
Carbonic anhydrase
inhibitors
(e.g., acetazolamide)
Nat-Cl symport
Na and HCO;-
reabsorption
Aldosterone
antagonists
(e.g., spironolactone)
Nat channel
(indirect effect)
Loop diuretics (e.g., furosemide)
Amiloride,
#triamterene
Nat-K+-2CF symport
Na channel
(direct effect)
#NaCI reabsorption
Thiazide diuretics ... Aldosterone antagonists ... effect) Loop diuretics
Heart Failure Medications Summary
Inhibitors of the Renin-Angiotensin System:
 • ACE Inhibitors: Benazepril, Captopril, Enalapril, Lisinopril, Quinapril,
Mineralocorticoid Receptor Antagonists ... Sacubitril/valsartan Diuretics ... Metolazone • Loop Diuretics
Here’s a review of the Renin-Angiotensin-Aldosterone system (RAAS)

This is a very common pathway that clinicians should
and Aldosterone Antagonists ... an Aldosterone antagonist ... potassium-sparing diuretic