6542 results
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Erythematosus - Diagnosis ... 5-10% - Anti- ... Differential Diagnosis ... Erythematosus #Diagnosis ... autoantibodies #signs
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
, anti-Mi-2, anti-TIF ... heliotrope, shawl sign ... Associated Features: Diagnosis ... over years, often diagnosed ... #differential #diagnosis
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
heliotrope rash, Shaw sign ... , holster sign, ... /full triad at diagnosis ... and anti-HMGCR ... Autoimmune #Myositis #diagnosis
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings
Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
-1, Anti-OJ, Anti-Mi2 ... , Anti-SRP, Anti-EJ ... , Anti-PL12, Anti-PL7 ... Polymyositis #PM #Diagnosis ... Pathophysiology #Signs
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
ANTI-MDA5 DERMATOMYOSITIS ... chest (in a V-sign ... shoulders (in a shawl sign ... Inverse Gottron’s sign ... #dermatology #diagnosis
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
- Differential Diagnosis ... Lack of UMN/LMN signs ... /SSA, anti-La/SSB ... , anti-Sm, and anti-RNP ... #Differential #Diagnosis
Rheumatoid Arthritis Summary
Overview: chronic, inflammatory symmetric polyarthritis involving small joints of hands/feet, knees, shoulders
Signs & Symptoms:
knees, shoulders Signs ... rheumatoid factor) • anti-CCP ... • Ultrasound Diagnosis ... : CLINICAL DIAGNOSIS ... • Biologics: Anti-TNF
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
and Differential Diagnosis ... clinical context and signs ... Vasculits: ANCA, ANA, Anti-GBM ... , Anti-ds-DNA, C3 ... #Differential #Diagnosis
Maculopapular - Diagnostic Algorithm
Pathophysiology:
- Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
Maculopapular - Diagnostic ... Ill-appearing, vital sign ... introduction of anti-convulsant ... Immunocompromised #Diagnosis
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features
 • RA affects 1% of population, women >
antibodies -> Anti-Cyclic ... Extra-articular signs ... pathophysiology #signs ... #symptoms #diagnosis