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Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
Pathogenesis and clinical ... a maladaptive antibody-mediated ... specific pre-formed antibodies ... produce autoimmune antibodies ... entire complex -> Antibody
Clinical Manifestations and Diagnosis of Lyme Disease - Borreliosis Erythema migrans - 3-32 days (median: 7-10 days)
Clinical Manifestations ... High specific IgG antibody ... Intrathecal specific antibody ... of specific IgG antibodies ... of specific IgG antibodies
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
- 1 or more clinical ... • Cardiolipin Antibodies ... • Prothrombin Antibody ... • Cardiolipin Antibody ... Glycoprotein 1 Antibody
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Erythematosus Clinical ... Antiphospholipid antibody ... Highly specific antibodies ... domain: Anti-dsDNA antibody ... , Anti-Sm antibody
Type I Hypersensitivity: Pathogenesis and clinical findings Definition: Production of lgE Antibodies that bind to harmless allergens
Pathogenesis and clinical ... Production of lgE Antibodies ... that secrete lgE-antibodies ... creating an allergen-antibody ... -> Allergen-antibody
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings The epidemiology of this disease is 1/340,000 births and roughly double
Pathogenesis and clinical ... decline in maternal antibody ... immunoglobulin proteins (antibodies ... or undetectable antibodies
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... or Anti-NucIear Antibody ... refers to antibodies ... likely it will be clinically ... #Antinuclear #Antibodies
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS) Fracture, Osteoporosis - Increased osteoclast activity and bone resorption
Reduction in specific antibody ... Neuropathy - Antibodies ... rituximab (in clinical
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
- Antinuclear antibody ... double-stranded DNA antibodies ... peptide (CCP) antibody ... persons - CCP antibody ... ANA and RF (if clinical
Toxocariasis Pathogen: Toxocara - worldwide distributed helminth Transmission: • Dogs and cats are the major source
• History + clinical ... eosinophilia • ELISA antibody ... detect human IgG antibodies
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