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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Microangiopathies In Systemic Lupus ... Microangiopathies #Systemic #Lupus ... Erythematosus #SLE #hematology ... #rheumatology # ... differential #diagnosis #causes
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
ANA level above laboratory ... - Anti-dsDNA antibody ... level above laboratory ... the presence of antibody ... #Diagnosis #Rheumatology
Bayesian combination of 4T score with Heparin PF4 antibody titer to obtain the post-test probability of
with Heparin PF4 antibody ... Bayesian #Diagnosis #Hematology ... Thrombocytopenia #Laboratory
Causes of Hemolytic Anemia - Differential Diagnosis
Inherited
 • Membrane
 • Internal
    - Hemoglobin
Causes of Hemolytic ... Membrane - Antibody ... Differential #Diagnosis #Causes ... #hematology
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Lupus (SLE): ... (anti-nuclear antibody ... Antiphospholipid Antibody ... glycoprotein I (ß2GP), Lupus ... #associations #table
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Diseases: • Systemic lupus ... hemoglobinuria • Antibody-mediated ... Differential #Diagnosis #Hematology
Differential Diagnosis of Palmar and Plantar Rashes
#Diagnosis #Dermatology #Rashes #Palmar #Plantar #Palms #Soles #Differential #Causes #Table
Rashes #Diagnosis #Dermatology ... #Differential #Causes ... #Table
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Antiphospholipid-antibody ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... differential #diagnosis #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
calcium-b) • Laboratory ... Discontinuation of causal ... versus DIL • Laboratory ... sle #comparison #table ... #rheumatology #
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
activity (e.g. antibody ... Study #diagnosis #hematology ... pathophysiology #hematology ... #laboratory