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diagnosis hematology rheumatology management oncology photo skin comparison sle syndrome vasculitis causes classification erythematosus hemolytic hodgkins lymphoma manifestations signs skinrash
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
69% - Malar rash ... - Hemolytic anemia ... , Cutaneous mimickers ... Other auto-immune, Infectious ... diseases, Hematological
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Congenital Diseases ... deficiency • Fanconi’s anemia ... : • Systemic lupus ... deficiency Infections ... #Diagnosis #Hematology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Joint Pain Rash ... Malar rash ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... #skin #rashes #differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... permanent alopecia Differential ... fibromyalgia) • Infections ... lymphoproliferative syndrome Clinical ... lymphopenia, low PLT • Anemia
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... usually IgG) (e.g. lupus ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
Connective tissue disease ... vasculitis (3%) • Infections ... Vasculitis #dermpath #dermatology ... lesions #diagnosis #clinical ... pathology #lesions #differential
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
appearing during the disease ... Infectious manifestations ... myelodysplastic #syndrome #differential ... #diagnosis #dermatology ... #oncology #clinical
Vibrio Vulnificus skin infection Cirrhosis w/recent consumption of raw oysters w/rapidly evolving rash. Vibrio vulnificus part of
chronic liver disease ... hemochromatosis, hemolytic anemia ... Diseases Fellowship ... #dermatology #legs ... #clinical #photo
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... NPSLE rare, Malar rash ... Rare (SSA+ for cutaneous ... Evolution: Chronic disease ... sle #comparison #table
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Clinical Presentation ... presentation) • Cutaneous ... • Symptoms of anemia ... younger pts) Differential ... #hematology #diagnosis
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