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diagnosis differential algorithm hematology causes management clinical pathophysiology neurology workup nephrology symptoms signs pharmacology comparison table hemolytic physicalexam treatment cardiology
Aplastic Anemia and Bone Marrow Failure Syndromes with Pancytopenia Fanconi Anemia Acquired Aplastic Anemia Dyskeratosis Congenita & Telemore Biology
Aplastic Anemia ... Acquired Aplastic ... Anemia Dyskeratosis ... BoneMarrow #Failure #Aplastic ... #anemia #diagnosis
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... @ZhuoerXie #Aplastic ... #Anemia #diagnosis
Causes of Aplastic Anemia #Aplastic #Anemia #Causes #Pathophysiology #Pathology #Treatment #Management #Differential
Causes of Aplastic ... Anemia #Aplastic ... #Anemia #Causes
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... • Marrow Aplasia ... Microangiopathic Hemolytic Anemias ... #Normocytic #Anemia
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... mutations) • Immune Aplastic ... HIV • Immune Aplastic ... consistent with aplastic
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... • Symptomatic anemia ... megaloblastic anemia ... Medicine @SCVMCMed #Aplastic ... #Anemia #diagnosis
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach to Anemia ... Sideroblastic anemia ... Non-hemolytic: ACD, Aplastic ... anemia, CKD • ... MatthewHoMD #Anemia
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... Deficiency • Aplastic ... Anemia • Anemia ... Non-lmmune #Anemia
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
particular degree of anemia ... Index < 2: • Anemia ... marrow failure: Aplastic ... anemia, Marrow ... Hospital-acquired anemia
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
• Toxins • Aplastic ... Anemia • Myelodysplasia
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