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hematology differential oncology management algorithm workup chronic leukemia lymphocytic mds myelodysplastic pathophysiology syndrome thrombocytosis acidosis approach ascorbicacid cell common cvid
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... • RBC Membrane Disorder ... #Classification ... #Algorithm #Causes ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... • Rheumatic disorders ... effect following treatment ... Iron deficiency anemia ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... ) (e.g. lupus, CLL ... lymphoproliferative disorders ... #hematology #anemia
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... changes), high MCV anemia ... not required in all ... #Differential #Diagnosis ... #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... Chronic inflammatory disorders ... myeloid leukemia (CML ... #Causes #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... lymphoproliferative disorders ... • Neutropenia, anemia ... microglobulin Treatment ... Lymphocytic #Leukemia #diagnosis
Skin Ulcers by Etiology - Differential Diagnosis Algorithm Physical: • Trauma • Pressure • Radiation Vascular: • Arterial
- Differential Diagnosis ... • Factitious disorder ... Anemia • Thalessemia ... ulcerative #skinrash #dermatology ... #Algorithm #causes
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
old, ~10,000 new cases ... cytopenias (usually anemia ... Allogeneic stem cell ... #Management #treatment ... #hematology #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
leukemia in adults • Disorder ... minimal tumor burden Diagnosis ... 5) Symptoms of anemia ... marrow failure with anemia ... #hemeonc #diagnosis
Clinical Classification of Pulmonary Hypertension 1. Pulmonary arterial hypertension from pulmonary vasculopathy Idiopathic pulmonary arterial hypertension Heritable gene mutations
Clinical Classification ... Chronic hemolytic anemia ... pulmonary Langerhans cell ... #Diagnosis #Differential ... #Causes
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