13 results
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Hemolysis - Diagnostic ... breakdown • Anaemia ... #Hemolytic #Anemia ... #Algorithm #Differential ... GrepMed Recommended Text
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... Differential Diagnosis ... Donath-Landsteiner HA (paroxysmal ... #Anemia #AIHA #
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... anemia): ... Transfusion reaction, Paroxysmal ... Extravascular #Causes #differential ... diagnosis #hematology #anemia
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... incompatibility • Paroxysmal ... udaygulati #Hemolytic ... #Anemia #Differential
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Microangiopathic Hemolytic ... spherocytosis, Autoimmune hemolytic ... Cold autoimmune hemolytic ... anemia, Paroxysmal ... RBC #Morphology #differential
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Pancytopenia - Differential ... deficiency • Fanconi’s anemia ... erythematosus • HLH • Paroxysmal ... Antibody-mediated hemolysis ... #Pancytopenia #Differential
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
anemia • Cold ... younger pts) Differential ... macroglobulinemia Paroxysmal ... • Diagnostic Test ... Donath-Landsteiner test
Benign Adrenal Mass - Differential Diagnosis Algorithm
Hyperplasia - Often Bilateral
 • Congenital Adrenal Hyperplasia
 • ACTH
Adrenal Mass - Differential ... Dexamethasone Suppression Test ... Pheochromocytoma (Paroxysmal ... AdrenalMass #Benign #Differential ... Diagnosis #Algorithm #Endocrinology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
value is low, tests ... result in severe anemia ... indirect antiglobulin tests ... anemia Indirect ... WBC count and differential
Hyperuricemia - Differential Diagnosis Algorithm
Primary - Over-production
     • Increased turnover of nucleotides
Primary
Hyperuricemia - Differential ... Leukemia (CML) - Hemolytic ... Anemia - Others ... Hyperuricemia #Differential ... Diagnosis #Algorithm #endocrinology