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hematology algorithm anemia hemolytic causes adrenalmass autoimmune classification workup acromegaly agglutinin aiha antiglobulin atlas benign blood bloodcell cold dat direct
Expected DAT Results in Autoimmune Hemolysis DAT Negative Hemolysis • DAT Poly ( - ), IgG (
in Autoimmune Hemolysis ... DAT Negative Hemolysis ... , C3d ( +/- ) Paroxysmal ... #antiglobulin #test ... #hematology #diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... for Hemolysis - ... Transfusion reaction, Paroxysmal ... Extravascular #Causes #differential ... #diagnosis #hematology
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic ... #Algorithm #Differential ... Causes #Workup #Hematology ... #Diagnosis * ... GrepMed Recommended Text
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Diagnosis Table ... Donath-Landsteiner HA (paroxysmal ... #Diagnosis #Table ... #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... Diagnosis Congenital ... erythematosus • HLH • Paroxysmal ... Antibody-mediated hemolysis ... #Diagnosis #Hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... incompatibility • Paroxysmal ... #Diagnosis #causes ... classification #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... younger pts) Differential ... macroglobulinemia Paroxysmal ... test #cold # ... #anemia #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Laboratory Tests ... #Differential # ... Diagnosis #hematology
Benign Adrenal Mass - Differential Diagnosis Algorithm Hyperplasia - Often Bilateral • Congenital Adrenal Hyperplasia • ACTH
Adrenal Mass - Differential ... Diagnosis Algorithm ... Dexamethasone Suppression Test ... Pheochromocytoma (Paroxysmal ... #Endocrinology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
activity is the diagnostic ... value is low, tests ... indirect antiglobulin tests ... WBC count and differential ... #Workup #Hematology
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