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diagnosis hematology hemolytic causes hemolysis agglutinin aiha aplastic atlas autoimmune bloodcell disease disorders extravascular intravascular management microscopy morphology nomenclature oncology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic Anemia ... (AIHA) - Differential ... Donath-Landsteiner HA (paroxysmal ... #AIHA #Differential ... Diagnosis #Table #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... deficiency • Fanconi’s anemia ... erythematosus • HLH • Paroxysmal ... #Differential # ... Diagnosis #Hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... • AIHA: warm, cold ... incompatibility • Paroxysmal ... Diagnosis #causes #classification ... #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... Cell Agglutinate: Cold ... , Paroxysmal cold ... RBC #Morphology #differential ... #diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
younger pts) Differential ... macroglobulinemia Paroxysmal ... • Diagnostic Test ... Donath-Landsteiner test ... #hematology #diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Transfusion reaction, Paroxysmal ... Autoimmune (AIHA)"Cold ... (e.g. primary cold ... Extravascular #Causes #differential ... #anemia
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
bone marrow + pancytopenia ... Anticonvulsants - Gold ... marrow-failure syndromes • Paroxysmal ... • Peripheral Pancytopenia ... #oncology #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... practices that could ... K), H. pylori test ... changes), high MCV anemia ... ITP, unexplained pancytopenia
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Autoimmune: Warm AIHA, Cold ... Defects: Sickle cell anemia ... Laboratory Tests ... #Diagnosis #hematology
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