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diagnosis hematology hemolysis aiha algorithm antiglobulin atlas bloodcell causes cold dat direct disease extravascular intravascular microscopy morphology nomenclature rbc red
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... Donath-Landsteiner HA (paroxysmal ... hemoglobinuria) • Cold Agglutinin ... #Hemolytic #Anemia
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral infection, autoimmune ... younger pts) Differential ... macroglobulinemia Paroxysmal ... • Diagnostic Test ... #anemia #hematology
Expected DAT Results in Autoimmune Hemolysis DAT Negative Hemolysis • DAT Poly ( - ), IgG (
DAT Results in Autoimmune ... ( +/- ) Cold agglutinin ... , C3d ( +/- ) Paroxysmal ... #antiglobulin #test ... #Hemolysis #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... deficiency • Fanconi’s anemia ... Inflammatory and Autoimmune ... erythematosus • HLH • Paroxysmal ... Antibody-mediated hemolysis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... Transfusion reaction, Paroxysmal ... . primary cold agglutin ... Extravascular #Causes #differential ... #anemia
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Agglutination - Cold agglutinins ... elliptocytosis, autoimmune ... #Anemia #Differential
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
hemolytic anemia ... hemolytic anemia ... , Paroxysmal cold ... RBC #Morphology #differential ... #diagnosis #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Membrane): - Autoimmune ... Defects: Sickle cell anemia ... Laboratory Tests ... Diagnosis #hematology
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