29 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... Puncture, EEG Treatment ... (for secondary APS ... cerebritis #diagnosis #management ... #treatment
Algorithm for the Treatment of Membranous Lupus Nephritis
Sub-nephrotic-range proteinuria (<3.5g/d, normal serum albumin) and Preserved kidney
Algorithm for the Treatment ... of Membranous Lupus ... proteinuria (<3.5g/d, normal ... #Membranous #Lupus ... #management #nephrology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... organ damage • Treatment ... Lysis Syndrome: • Pathophysiology ... #diagnosis #management ... #hematology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Epidemiology: -10% of all ... constitutional symptoms • Treatment ... life-threatening • Treatment ... Usual therapeutic management ... rheumatology #diagnosis #management
Polycythemia Vera (PV) - Diagnosis and Management Summary
Diagnostic Criteria:
 • Elevated hemoglobin and/or hematocrit AND
 •
Diagnosis and Management ... JAK2 mutation OR Abnormally ... : • As with ET ... PV #Diagnosis #Management ... #hematology
Hepatitis B - Treatment Indications
Treatment not indicated:
 • Immune tolerant state - HBe-Ag detectable, high HBV
(>10^6 IU/mL), normal ... (<2000 IU/mL), normal ... ALT Treatment ... #Indications #management ... #hepatology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
upper limit of normal ... Hepatitis (eg Viral) Management ... regarding need for treatment ... AIH #Diagnosis #Management ... #Hepatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... Pathophysiology ... 500 mg QD until normal ... APML #diagnosis #management ... #hematology #oncology
Intracranial Hemorrhage (ICH) and Increased Intracranial Pressure (ICP) - Pathophysiology
ICH Management:
1. Manage Blood Pressure
  •
Pressure (ICP) - Pathophysiology ... ICH Management ... lidocaine, +/- pre-treatment ... reduces ICP (but also ... #management
Vasospastic (Prinzmetal) Angina
Definition / Epidemiology:
 • Rest angina attributed to coronary artery vasospasm.
 • Patients often
younger than other ACS ... Pathophysiology: ... • Normal exercise ... tests in cath lab Treatment ... cardiology #diagnosis #management