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Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Intravascular Coagulation (DIC ... • Prolonged PT/PTT ... Manifestations of DIC ... PT/INR: ↑ • PTT ... INR < 2.3 - APTT
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Abnormal PT and/or aPTT ... typically prolong aPTT ... may prolong the aPTT ... Prolonged PT and aPTT ... intravascular coagulation (DIC
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
Thromboplastin Time (PTT ... Thromboplastin Time (PTT ... elevated in: • DIC ... thematttsai #PT #PTT
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Prolonged PT and aPTT ... the PT and the aPTT ... intravascularcoagulation (DIC ... #Abnormal #PT #aPTT
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC)
Platelet count:
 • Expected: Low (or normal)
 • Elevation
Intravascular Coagulation (DIC ... aggregation PT, aPTT ... small vessels #DIC
Therefore, studies obtained at the initial presentation in the emergency department should evaluate for fibrinolysis with
thromboplastin time (PTT ... decompensated DIC ... Diagnosis #Honc #DIC
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
NORMAL PT/NORMAL PTT ... Perform a PTT mixing ... Warfarin • Acute DIC ... the PT and the PTT ... disease • Acute DIC
Pediatric Skull Fracture with Associated Hematoma on POCUS

Working with the challenges of risk stratification, management of
Associated Hematoma on POCUS ... setting, where skull pocus ... Tough decisions: dc ... Fracture #Hematoma #POCUS
Effect of Direct Oral Anticoagulants on Hemostatic Tests
Horizontal bars correspond to the approximate range of detectability
Ranges are approximations ... laboratory #testing #aptt
Comparison of Ocular Pathologies on POCUS:
 • Vitreous Detachment
 • Vitreous Hemorrhage
 • Retinal Detachment

Vitreous detachment
Pathologies on POCUS ... tethers to the optic disc ... EUSmkh #Ocular #POCUS