20 results
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
Acute Rheumatic Fever ... • Arthralgia ... Pancarditis and valvular ... RheumaticFever #pathophysiology ... #diagnosis #signs
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
– symptoms and signs ... coarse skin, Arthralgia ... Carpal timel syndrome ... Myotonia, Muscular ... #PhysicalExam #Endocrinology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Deposition - Arthralgia ... trabecular thinning -> Avascular ... Myopathy (Also caused ... Complications #pathophysiology ... #signs #symptoms
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
• Other rare causes ... Carpal Tunnel Syndrome ... arrhythmia • Valvular ... Overproduction #diagnosis #signs ... #symptoms #endocrinology
Primary Adrenal Insufficiency
Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
aldosterone Causes ... : Most Common Causes ... • Low-grade fever ... Back pain • Arthralgia ... addisons #disease #endocrinology
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
characterized by fever ... Disorder: - Fever ... Episcleritis Signs ... (arthritis and arthralgia ... Causes: - Idiopathic
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
hypertension and signs ... renal bruit or signs ... Causes: • Vascular ... Vasculitis • Endocrinologic ... White-coat syndrome
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... symptoms are not caused ... General: fever, ... : ACUTE, fever, ... Diagnosis #Management #Signs
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... - 80% have fever ... WBC >100k, + lab signs ... : • Pathophysiology
Lung Infections in HIV - Differential Diagnosis Framework

Disease by CD4 Count:
Any CD4 Count:
 • Mycobacterium tuberculosis,
Pneumonia: • 3 syndromes ... • CT: Halo sign ... of a "flu-like syndrome ... factor • May cause ... ), anemia, arthralgia