24 results
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
Acute Rheumatic Fever ... • Arthralgia ... Pancarditis and valvular ... RheumaticFever #pathophysiology ... #diagnosis #signs
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Deposition - Arthralgia ... trabecular thinning -> Avascular ... Myopathy (Also caused ... Complications #pathophysiology ... #signs #symptoms
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Etiology: • Vascular ... Kasabach-Merritt syndrome ... Gardner-Diamond syndrome ... mountain spotted fever ... #rheumatology #
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... : - Arthralgia ... Cryoglobulins Cause ... Vascular Sludging ... classification #rheumatology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... - 80% have fever ... WBC >100k, + lab signs ... : • Pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... • Other rare causes ... Carpal Tunnel Syndrome ... arrhythmia • Valvular ... Overproduction #diagnosis #signs
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
characterized by fever ... Disorder: - Fever ... Episcleritis Signs ... (arthritis and arthralgia ... Causes: - Idiopathic
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... symptoms are not caused ... General: fever, ... : ACUTE, fever, ... Diagnosis #Management #Signs
Lung Infections in HIV - Differential Diagnosis Framework

Disease by CD4 Count:
Any CD4 Count:
 • Mycobacterium tuberculosis,
Pneumonia: • 3 syndromes ... • CT: Halo sign ... of a "flu-like syndrome ... factor • May cause ... ), anemia, arthralgia
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Night sweats • Arthralgias ... purpura: Strong sign ... pulse deficits vascular ... tract, and often causes ... Differential #Diagnosis #Rheumatology