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diagnosis hematology anemia blood classification management product purpura bruising conjugated extravascular fever framework hemolysis infectiousdiseases intravascular jaundice nonpalpable palpable peds
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... microangiopathy: Thrombotic thrombocytopenic ... Extravascular #Causes ... #differential # ... diagnosis #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... • Transfusion reactions ... #Anemia #Differential ... classification #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... inflammation • Thrombocytopenia ... : - Thrombocytopenia ... DIC/TTP/HUS - Hemolytic ... fever • Drug reactions
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... severe thrombocytopenia ... TRALI): Leading cause ... Can lead to sepsis ... diagnosis #management #hematology
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... - Differential ... - Bacterial: Sepsis ... #Differential # ... Diagnosis #Framework #hematology
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
production (eg, hemolytic ... anemias, hemolytic ... reactions, hematoma ... syndrome, drug reactions ... #unconjugated #differential
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Causes purpura & ... severe thrombocytopenia ... TRALI): Leading cause ... more likely to cause ... Can lead to sepsis
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
for Thrombotic Thrombocytopenic ... decrease in most cases ... WBC count and differential ... hematuria (without casts ... Diagnosis #Workup #Hematology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... Non-immune - Haemolytic ... Purpura #Bruising #Causes ... #peds #pediatrics ... #diagnosis #differential
Fever After International Travel Infectious Disease: • Endemic in either the destination or home region Viral Syndromes: Arboviral infections, a
aches, leukopenia, thrombocytopenia ... bilirubin levels, thrombocytopenia ... No hemolytic anemia ... polymerase-chain-reaction ... Fever #Travel #Differential
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