15 results
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
Differential diagnosis ... syndrome (ST-HUS ... transplant • DIC ... anemia" • HELLP syndrome ... #diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
intravascular coagulation (DIC ... ) - HELLP syndrome ... uremic syndrome ... Extravascular #Causes #differential ... #diagnosis #hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... MAHA: TTP, HUS, DIC ... Drug-associated, PCH, Evans Syndrome ... #Differential # ... Diagnosis #hematology
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Myelodysplastic syndrome ... uremic syndrome ... coagulopathy (DIC ... key #diagnosis #differential ... #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... /TTP/HUS - Hemolytic ... Kasabach-Merritt syndrome ... Gardner-Diamond syndrome ... #nonpalpable #dermatology
Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Thrombocytopenia - Differential ... - Bacterial: Sepsis ... Microangiopathy: DIC ... antiphospholipid syndrome ... Diagnosis #Framework #hematology
Gangrene of the Hand: Sepsis induced DIC has led to extensive arterial thrombosis, resulting in
profound tissue
Gangrene of the Hand: Sepsis ... induced DIC has ... Photo credit, Josh ... #Dermatology #Gangrene ... #Hand #DIC #Photo
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
necrosis HELLP Syndrome ... (Hemolysis, Elevated ... features: Hemolysis ... DIC • Aminotransferases ... hepatitis #comparison #differential
Capnocytophaga Canimorsus Skin Rash

40 M presents w/ N, V, severe epigastric pain. SHx: smoker, drinks 18
bacillus cause selsis ... inflammation persist → DIC ... possible Patient's clinical ... Canimorsus #Skin #Rash #dermatology ... #clinical #photo
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... Diagnosis: • hemolytic ... younger pts) Differential ... #anemia #hematology