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diagnosis hematology coagulation hellp obstetrics pregnancy thrombocytopenia algorithm aptt hepatitis lfts prolonged ttphus acronym biliary bleeding bruising chemistry cholangitis cirrhosis
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
of Pregnancy (AFLP ... DIC • Aminotransferases ... Disease #Pregnancy #hepatology ... obstetrics #hepatitis #comparison ... #differential #
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
of Pregnancy (AFLP ... schistocytes, DIC ... child * Severe cases ... #diagnosis #table ... #comparison
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
schistocytes, DIC ... child * Severe cases ... TTPHUS #HELLP #AFLP ... #Diagnosis #Comparison ... #Table
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... • Reduced liver ... intravascularcoagulation (DIC ... amyloidosis #Abnormal ... #differential #
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
history of trauma, sepsis ... • Prolonged PT ... Fibrinogen: ↓ • PT ... • Severe Liver ... Treat primary cause
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... • Pregnancy - AFLP ... Others #LFTs #Hepatology ... Diagnosis #Algorithm #Causes
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... intravascular coagulation (DIC ... #differential #
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Algorithm Vascular Causes ... Injury: • Hepatic ... function may be abnormal ... diagnosis #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Coagulation factors: PT ... replaced by non-hepatic ... • Near normal ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... Acquired: • Heparin ... PT/NORMAL PTT: ... ABNORMAL PT/
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