9 results
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Causes of Extravascular ... - Differential ... anemia • ... MAHA (TTP, DIC, HUS ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... anemia): ... uremic syndrome (HUS ... #differential # ... #anemia
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... • MAHA: TTP, HUS ... #Anemia #Differential ... classification #hematology
Jaundice - Differential Diagnosis Algorithm
Pre-Hepatic - Unconjugated Hyperbilirubinemia
Increased Production
 • Hemolysis
 • Ineffective Erythropoiesis
 • Hematoma
Decreased
Jaundice - Differential ... Production • Hemolysis ... Hepatic Uptake • Sepsis ... Diagnosis #Algorithm #Causes ... #Hepatology #bilirubinemia
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
Fibrin degradation products ... result in severe anemia ... anemia Indirect ... WBC count and differential ... Diagnosis #Workup #Hematology
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Causes purpura & ... TRALI): Leading cause ... Occurs between 0-6 hrs ... more likely to cause ... Can lead to sepsis
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... TRALI): Leading cause ... Occurs between 0-6 hrs ... Can lead to sepsis ... diagnosis #management #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... disease - DIC/TTP/HUS ... - Hemolytic ... anemia - Splenomegaly ... : • DIC, TTP/HUS
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
persons • It has ... nodosum • Immune hemolytic ... anemia • Pain ... genes and gene products ... Immunohistochemical studies (to differentiate