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diagnosis hepatology blood causes gastroenterology hepatitis product reactions aclf aflp alcoholic chemistry chronic cirrhosis criticalcare drug druginduced fatty idiosyncratic induced
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Injury (DILI) ... #differential # ... gastroenterology #algorithm ... gastroenterology #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Liver Failure ( ... Injury (DILI) ... #Hepatology #gastroenterology ... #management #diagnosis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Stepwise Diagnosis Algorithm ... dechallenge • Acute ... disorder (e.g. ascites ... #Algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... Liver Injury: ... #hepatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... liver failure rapidly ... develops (DIC, ascites ... 10x ULN), ↑Tbili/Dbili ... infiltration) Differential
Causes of Ascites - Differential Diagnosis Algorithm Portal Hypertension - Prehepatic: • Portal vein thrombosis • Splenic
- Differential ... Diagnosis Algorithm ... Infiltrative disease • Acute ... liver failure ... #Hepatology #causes
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... • Infectious: Sepsis ... #Injury #Differential ... #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Failure ( ... Unconjugated Bili ... > 90% of Total Bili ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Shock - Differential Diagnosis Framework - MAP <65. SBP <90, drop in SBP > 40 -
Insufficiency, Liver ... Failure, Toxins ... Medications, Spinal Cord Injury ... #criticalcare #algorithm ... #treatment #management
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
blood, urine and ascites ... kidney injury with ... HCV, DILI, HCC, ... - Multiorgan failure ... #Algorithm #hepatology
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