2773 results
Causes of Developmental Delay - Differential Diagnosis Algorithm
Isolated Domain Delay - Reduced Respiratory Drive:
 • Cognitive
Impairment: • Autism ... • Selective Mutism
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
typically a drug) -> Macrophage ... Cells activate macrophages
Trichomonas on Urine Microscopy
Trichomonas organism adjacent to WBC’s and a macrophage - brightfield with SM stain
to WBC’s and a macrophage
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... Histopathologic features • Macrophage ... : Evidence of macrophage ... exchange #MAS #Macrophage ... Syndrome #Diagnosis #Management
Pediatric Mood & Anxiety Disorders - Differential Diagnosis Algorithm
Bipolar
Mood
• Major Depressive Disorder
• Persistent Depressive Disorder
• Disruptive
Disorder • Selective Mutism
Pathology - Hepatocyte Pigments

Lipofuschin (H&E) 

Alpha-I-antitrypsin globules (PAS-D) 

Mallory's hyaline / Mallory Denk Bodies 

Giant Mitochondria
/ ceroid-laden macrophage
Leishmaniasis Life Cycle
1) Sandfly takes a blood meal (injects promastigote stage into the skin)
Human Stages:
2) Promastigotes
phagocytized by macrophages ... meal (ingests macrophages
Rare Invasive Yeasts - Species and Antifungal Therapy

Cryptococcus, 
Geotrichum, 
Kodamaea, 
(Pichia)ohmeri, 
Malassezia, 
Pseudozyma, 
Rhodotorula, 
Saccharomyces, 
Saprochaete
Trichosporon, Candida auris ... Antifungal #Therapy #Management
Whipple Disease (Tropheryma whipplei) - Diagnosis and Management 

Caused by: Tropheryma whipplei

Symptoms and Signs:
1. Migratory poly/oligoarthralgia
Diagnosis and Management ... • PAS-positive macrophages ... diagnosis #algorithm #management
Gaucher Disease 

Pathophsiology
 • Lysosomal storage disorder
 • Deficiency of ß-glucocerebrosidase
• Accumulation of glucosylceramide in macrophages
Diagnosis
glucosylceramide in macrophages