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Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
characterized by fever ... dermatoses are autoinflammatory ... Disorder: - Fever ... Symptoms: - Fever ... Causes: - Idiopathic
PFAPA Syndrome - Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis

EPIDEMIOLOGY:
PFAPA is the most common syndrome entailing
PATHOPHYSIOLOGY: The exact cause ... believed to be an autoinflammatory ... Familial cold autoinflammatory ... It causes the absolute ... known pathogenic cause
Faget Sign - Pulse-Temperature Dissociation
Causes of Relative Bradycardia
 • Infectious Causes: Legionella, Psittacosis, Q fever, Typhoid
Dissociation Causes ... • Infectious Causes ... , Typhoid fever, ... Non-Infectious Causes ... differential #diagnosis #causes
Faget's Sign & Liebermeister's Rule
Pulse-Temperature Dissociation
EVERY 1 F RISE IN TEMPERATURE -> HR INCREASES 8-10 BPM
INFECTIOUS
BPM INFECTIOUS CAUSES ... • Typhoid Fever ... OTHER CAUSES ... There are specific cases ... #differential #causes
Childhood Immunization Schedule: Why we immunize
 • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
pharyngeal erythema, fever ... pharyngeal erythema, fever ... attack meninges -> Fever ... Sudden onset of fever ... pruritic rash, fever
Causes of Relative Bradycardia - Note the propensity for intracellular organisms.
Infectious: 
Legionella, Psittacosis, Q fever, Typhoid
Causes of Relative ... Psittacosis, Q fever ... , Typhoid fever, ... , Dengue fever, ... #bradycardia #Causes
Causes of Leukocytosis and Leukopenia - Differential Diagnosis
 • Eosinophilia (AEC > 500, hypereosinophilia > 1500):
Causes of Leukocytosis ... Marrow Failure, Autoinflammatory ... Differential #Diagnosis #causes
Fever Patterns - Differential Diagnosis Framework

Continuous Fever:
Temp > 38°C with only 1 degree fluctuation in 24
Fever Patterns - ... Continuous Fever ... (Step ladder: fever ... or no fever • ... Non-Infectious Causes
Causes of Fever by System #Diagnosis #EM #IM #Fever #Differential #Ddxof
Causes of Fever ... Diagnosis #EM #IM #Fever
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis
 • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
Causes of Fever ... Brucellosis, Q fever ... vasculitis to cause ... , Factitious fever ... Differential #Diagnosis #causes