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diagnosis management chronic differential hepatology nephrology oncology rheumatology syndrome acidosis aclf arthritis causes cirrhosis classification cll diuresis diuretics elevation encephalopathy
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... underlying liver disease ... Circulation Failure ... Kidney Failure
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
deficiencies: Chronic kidney ... disease, Hypothyroidism ... • Bone marrow failure ... Index > 3: • Acute ... #diagnosis #calculation
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
Inhibitors of Na+K+2Cl ... Torsemide) • Acute ... hyperaldosteronism • Acute ... Tolvaptan) • Treatment ... Excretion #Diuresis #Nephrology
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... lesions, meninges, kidneys ... hypergammaglobulinemia, ↑ acute ... management #phenotypes #workup ... #treatment #rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cells can indicate disease ... • Neutropenia, anemia ... • Bone marrow failure ... ’s lymphoma or acute ... #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... • Bone Marrow Failure ... Myeloproliferative Disease ... Workup: • Complete ... Syndromes #diagnosis #hematology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
may precede the neurologic ... Shock, Autoimmune disease ... agents, Renal failure ... : MCA ACA watershed ... syndrome, ADEM, Acute
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
presentations and disease ... before beginning treatment ... cardiac output - Acute ... peritonitis - Acute ... 30mmHg) - Severe anemia
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... the presence of anemia ... Screening Tests for Acute ... rubella titer, ACE ... Arthritis #laboratory #workup
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
advanced liver disease ... hepatitis, or acute ... liver failure ... Treatment Overview ... #Nephrology #Diagnosis
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