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diagnosis management differential nephrology hepatology aki algorithm causes liver rheumatology ckd classification hepatitis workup blood hyperkalemia kidneyinjury medications oncology product
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... underlying liver disease ... Kidney Failure ... Drug-Induced Liver Injury
Acute Kidney Injury - Classification Prerenal: • Dehydration • Heart failure (a.k.a. cardiorenal syndrome) • Liver failure
Acute Kidney Injury ... Dehydration • Heart failure ... syndrome) • Liver failure ... #Kidney #Injury ... Classification #diagnosis #nephrology
Causes of Acute Kidney Injury ( AKI ) - Prerenal, Renal, and Postrenal PRE-RENAL Impaired perfusion: •
Kidney Injury ( ... perfusion: • Cardiac failure ... • Inflammatory disease ... #Kidney #Injury ... #Differential #Nephrology
Acute Kidney Injury (AKI) in Patients with Cancer Cancer Related • Hypercalcemia • Intravenous contrast •
Acute Kidney Injury ... LC deposition disease ... • Hematologic ... malignancies Treatment ... #Kidney #Injury
Definitions of AKI, CKD, AKD Acute Kidney Injury (AKI): • Increase in SCr by 2 50% within
Kidney Injury ( ... • Oliguria Chronic ... Kidney Disease ... Kidney Diseases ... #Definitions #nephrology
Common causes of Acute Kidney Injury AKI - Differential Diagnosis HEMODYNAMIC • Cardiac failure: Impaired forward flow,
Kidney Injury AKI ... HEMODYNAMIC • Cardiac failure ... • Primary GNs: Disease ... Due to systemic disease ... Tubular Injury/
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
kidney disease, ... kidney disease, ... kidney disease ... kidney disease ... Tolvaptan) • Treatment
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... > 2 • NASH, Chronic ... > 3 • Chronic ... cardiac muscle, kidneys ... diagnosis #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Failure ( ... of cholestatic disease ... Alcoholic liver disease ... > 2 • NASH, Chronic ... > 3 • Chronic
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Skin involvement, Kidney ... non-essential drug/HDS treatments ... Alcohol-related liver disease ... dechallenge • Acute ... or chronic atypical
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