15 results
Fungal biomarkers
Beta-d-glucan
Aspergillus galactomannan

By Dr. Sara Dong @swinndong via Febrile [febrilepodcast.com]

#ID  #Infectious Diseases  #Infections
#Differential #Ddx
biomarkers Beta-d-glucan ... Fungal #Fungi #BDG #BDGlucan
1,3 Beta-D-Glucan and Galactomannan - Pathogens, and Testing Characteristics
1,3 ß-D-glucan:
 • Most fungi excluding mucor and
1,3 Beta-D-Glucan ... Characteristics 1,3 ß-D-glucan ... cellulose membranes), Glucan-containing
Beta-D-Glucan and Galactomannan - Venn Diagram of Fungal Infections

#BetaDGlucan #Galactomannan #Venn #Diagram #diagnosis #microbiology #infectiousdiseases #fungal
Beta-D-Glucan and
Fungal Biomarkers: Comparing Beta-D-Glucan and Aspergillus Galactomannan
Beta-D-Glucan:
 • Polysaccharide cell wall component of many fungi
 •
Comparing Beta-D-Glucan ... Galactomannan Beta-D-Glucan
Antifungal Echinocandins  - Antibiotics Class Overview

Mechanism: Inhibit glucan synthesis in fungal cell wall by blocking
Mechanism: Inhibit glucan ... blocking beta 1,3 D-glucan
(1,3)-β-d-glucan
Abundant cell wall polysaccharide, found in most fungi, except cryptococci, zygomycetes (mucor, rhizophus) and blastomyces.
Sensitivity 64%-93%;
(1,3)-β-d-glucan ... lack (1 ,3)-ß-d-glucan ... TheIDtrivia #beta #dglucan ... #glucan #betad
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan
Beta-D-Glucan:
 • Polysaccharide cell wall component of many fungi
 • Pathogens:
Biomarkers: Beta-D-Glucan ... Galactomannan Beta-D-Glucan
Invasive Candidiasis (IC)

Diagnosis:
Culture:
 • Gold standard, but Slow (~2-3 days), 50% sensitivity
 • Blood Sample
 •
tests: • Beta-D-Glucan
Fever - Pyrogen Pathophysiology

EXOGENOUS PYROGEN
 • Bacteria: Lipopolysaccharide components, peptidoglycans and muramyl peptide derivatives, Toxins
 •
Fungi: Mannan and glucan
Rigors And Bacteremia - Overview

• Rigors are a response to the release of cytokines and prostaglandins
Fungi: Mannan and glucan