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Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Diagnosis and Management ... • Immunologic Workup ... #Systemic #Erythematosus ... #Summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic Lupus ... Erythematosus ( ... #Erythematosus ... CNS #neurology #rheumatology ... cerebritis #diagnosis #management
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... #Systemic #Lupus ... #Erythematosus ... Summary #diagnosis #rheumatology ... #management
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
hypersensitivity reactions ... lgM antibodies bind ... Acute transfusion reaction ... glomerulonephritis, Systemic lupus ... erythematosus Type
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... Erythematosus ( ... • Immunologic Workup ... comparison #table #rheumatology ... #diagnosis #management
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
lgE antibodies bind ... , and systemic lupus ... erythematosus ... Allergy #Diagnosis #Reactions
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
erythematosus ... SJIA], systemic lupus ... erythematosus [ ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia
If prolonged or ≥ 39 C this is a
Hyperthermia - Guidelines ... transfusion • Allergic reaction ... Reference Handbook - Guidelines ... Checklist #Diagnosis #Management ... #Workup
Holistic Management of Systemic Lupus
 • Lifestyle interventions: Smoking cessation, Photoprotection, Therapeutic adherence, Anxiety/depression/fatigue, Fibromyagia/pain management,
Holistic Management ... of Systemic Lupus ... SLE #Systemic #Lupus ... #Erythematosus ... #rheumatology
Increased Airway Pressure - Guidelines for Crises in Anaesthesia

Using these steps from start to end should
Airway Pressure - Guidelines ... through the whole guideline ... Reference Handbook - Guidelines ... Checklist #Diagnosis #Management ... #Workup