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Algorithm for the Evaluation and Management of Transfusion Reactions

This algorithm was developed by Dr. Eric Madden,
Management of Transfusion ... Reactions This ... #Transfusion #Reactions ... #Algorithm #Diagnosis ... #Management #Hematology
Estimated Incidence of Transfusion Reactions
Graphical Depiction of transfusion reactions ordered from most highest to lowest incidence.
#Diagnosis
Reactions Graphical ... Depiction of transfusion ... reactions ordered ... #Diagnosis #Blood ... #Reactions #Events
Transfusion Reactions - Summary Cheatsheet
 • Hemolytic Reaction
 • Febrile Reactions
 • Transfusion Related Acute Lung
Transfusion Reactions ... Cheatsheet • Hemolytic Reaction ... • Febrile Reactions ... #Reactions #diagnosis ... #management #hematology
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Reaction (FNHTR ... Reaction (AHTR) ... Reaction (DHTR) ... #diagnosis #management ... #hematology #reactions
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Reactions Immune ... Reaction (FNHTR ... Reaction (AHTR) ... #diagnosis #management ... #hematology #reactions
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
TRALI vs TACO - Transfusion ... Reactions TRALI ... plasma volume transfusion ... #Reactions #hematology ... #diagnosis #comparison
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... HUS) • Other: Transfusion ... reaction, Paroxysmal ... reaction • Intrinsic ... #hematology #anemia
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... AIHA, Cold AIHA, Transfusion ... reactions, Drug-associated ... #Differential #Diagnosis ... #hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... prosthetic valve • Transfusion ... reactions ex. ... #Differential #Diagnosis ... classification #hematology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
- Differential Diagnosis ... Jaundice/Hemolytic reactions ... reaction - Tumor ... Blood transfusion ... #differential #diagnosis