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diagnosis differential injury dili hematology management causes chemistry cirrhosis drug druginduced failure hepatitis idiosyncratic induced interpretation lfts platelets rvalue transaminitis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... disease, liver ... #Acute #Chronic ... #Cirrhosis #Hepatology ... #gastroenterology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Differential Diagnosis Algorithm ... Infectious: • Acute ... or Chronic Inflammatory ... disorders • Celiac disease ... #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Approach to Thrombocytosis ... Differential Diagnosis Algorithm ... Vasculitides, IBD, Celiac disease ... • Infections: Chronic ... Differential #Diagnosis #Algorithm
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
presentation • Chronic ... disease 6-9 mo ... Diagnosis #Management #gastroenterology ... #algorithm #gastroenterology ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Differential Diagnosis Algorithm ... • NASH, Chronic ... injury: > 3 • Chronic ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
ALF): • Liver ... of cholestatic disease ... disease: > 2 ... • NASH, Chronic ... #differential #Hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... disease, Hepatic ... dechallenge • Acute ... or chronic atypical ... #hepatology
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