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diagnosis liver causes hematology transaminitis hepatitis acute anemia chemistry drug druginduced erythrocytosis fever function gastroenterology idiosyncratic immunecompromised immunocompromised induced interpretation
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
presentation • Chronic ... - ongoing ↑ LFTs ... symptoms of liver disease ... Idiosyncratic #differential ... gastroenterology #algorithm
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
) - Differential ... Cirrhosis • Chronic ... (>1000): • DILI ... Drug-induced liver injury ... Diagnosis #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Diagnosis Algorithm ... alternative causes • Hepatocellular ... Alcohol-related liver disease ... e.g. ascites), Chronic ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Diagnosis Algorithm ... • Iatrogenic: DILI ... : > 3 • Chronic ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Liver Injury Differential ... HELLP, Celiac disease ... #hepatology #algorithm ... Transaminitis #LFTs
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... : > 3 • Chronic ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
Anemia - Underproduction Diagnostic Algorithm - Iron deficiency anemia - Anemia of chronic inflammation - Anemia
- Anemia of chronic ... kidney disease ... disorder - TSH, LFTs ... #hematology #diagnosis ... #differential #
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
of Acute Liver Injury ... - Differential ... Hepatocellular ... Causes #Acute #algorithm ... #hepatology
Causes of Polycythemia (Erythrocytosis) - Differential Diagnosis Algorithm Relative - Normal RBC Mass / Decreased Plasma Volume
Erythrocytosis) - Differential ... Diagnosis Algorithm ... • Burns • Diarrhea ... #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Diagnosis Algorithm ... • Periodontal Disease ... Bronchitis • Chronic ... Diarrhea • Giardia ... #Causes #Hematology
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