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diagnosis rheumatology differential lupus symptoms arteritis behcet classification clinical comparison complications cutaneous dermatology dermpath disease druginduced erythematosus gca giantcell lesions
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
Identification of causes ... disease (10%) : SLE ... #dermpath #dermatology ... #semiology #signs ... diagnosis #clinical #manifestations
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
1 • Clinical Manifestations ... Alopecia, oral ulcers ... • Laboratory Manifestations ... Positive in 60-80% of cases ... #Summary #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Discontinuation of causal ... Alopecia, oral ulcers ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Manifestations ... hair follicles -> causes ... > Mouth, Nasal Ulcers ... Livedo Reticularis, Vasculitis ... pathophysiology #diagnosis #signs
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
M > F Clinical Manifestations ... Oral aphthae : SLE ... Syndrome #diagnosis #management ... #signs #symptoms ... #rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... livedo reticularis, ulcers ... genital aphthous ulcers ... purpura: strong sign ... , and SLE) • Urinalysis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... purpura: Strong sign ... livedo reticularis, ulcers ... tract, and often causes ... genital aphthous ulcers
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic inflammatory vasculitis ... Manifestations depend ... systemic sx + signs ... GCA #Temporal #Signs ... Symptoms #Diagnosis #Management
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