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diagnosis differential rheumatology classification symptoms acute behcet clinical complications cryofibrinogenemia cryoglobulinemia cryoglobulins cutaneous dermatology dermpath disease hiv infections infectiousdiseases lesions
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
Identification of causes ... disease (10%) : SLE ... #dermpath #dermatology ... #semiology #signs ... diagnosis #clinical #manifestations
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Autoimmune • ITP • SLE ... Non-lmmune: • HELLP Syndrome ... HUS • DIC • Vasculitis ... #Causes #Hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
M > F Clinical Manifestations ... Oral aphthae : SLE ... • Arthritis: SLE ... diagnosis #management #signs ... #symptoms #rheumatology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Manifestations ... hair follicles -> causes ... > Mouth, Nasal Ulcers ... Livedo Reticularis, Vasculitis ... pathophysiology #diagnosis #signs
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Purpura - Skin ulcers ... Cryoglobulins Cause ... diseases: - 10% SLE ... erythematosus (SLE
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... livedo reticularis, ulcers ... genital aphthous ulcers ... purpura: strong sign ... , and SLE) • Urinalysis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... purpura: Strong sign ... tract, and often causes ... • Behcet syndrome ... • Cogan syndrome
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
malignancies, vasculitis ... sensitivity • Painful ulcers ... cryoglobulins • Negative causes ... Antiphospholipid syndrome ... #hematology
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
24%) • Mouth ulcers ... , vomiting, diarrhea ... nervous system manifestations ... 14%), in which case ... • New onset SLE
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
status NTM Cause ... : • Syndrome of ... Hematologic malignancy ... liver enzymes, diarrhea ... Disease: Clinical Manifestations
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