71 results
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
- Differential Diagnosis ... : • GATA2 deficiency ... Wiskott-Aldrich syndrome ... erythematosus • HLH ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
- Differential Diagnosis ... : • Acute or Chronic ... disorders • Celiac disease ... effect following treatment ... malignancy • Iron deficiency
Hypophosphatemia - Differential Diagnosis Algorithm

Transcellular Shift
 • Recovery From DKA
 • Refeeding Syndrome
 • Acute Respiratory
- Differential Diagnosis ... • Refeeding Syndrome ... • Small bowel diarrhea ... • Anorexia • Chronic ... Inflammatory Bowel Disease
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... • Autoimmune diseases ... Cellular immune deficiency ... #management #treatment
Korsakoff Syndrome
Clinical Findings:
 • Confabulation: Usually initial phase of the disease
 • Anterograde amnesia: Memory impairment
Clinical Findings ... initial phase of the disease ... Chronic presentation ... of Thiamine deficiency ... #neurology #diagnosis
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Clinical Presentation ... • HLH Labs: ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Acute hemolysis, deficiency ... Rebound effect from treatment ... Vasculitides, IBD, Celiac disease ... Kawasaki, Nephrotic syndrome ... • Infections: Chronic
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... syndrome associated ... age, however the disease ... • Bicytopenia Treatment ... #hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
Diagnostic Framework ... kidney disease, ... Myelodysplastic syndrome ... #differential #diagnosis ... #causes #hematology
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
α1-antitrypsin deficiency ... heart failure (chronic ... (Budd-Chiari syndrome ... 14 percent) #Diagnosis ... #Differential #Hepatology
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