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diagnosis neurology hepatology management algorithm causes lfts autoimmune disorders sclerosis spinalcord transaminitis weakness workup aih als amyotrophic atrophy biliary calcium
Upper Motor Neuron (UMN) lesions are lesions occurring anywhere in the CNS from the brain up
Motor Neuron (UMN ... form part of the differential ... However, in UMN ... and a positive Babinski ... @DharSaty #UMN
Incomplete spinal cord syndromes (ISCS) • Central - Small Lesion - Suspended sensory deficit, classic cape
Incomplete spinal cord ... lesion of cervical cord ... Disproportionate motor (UMN ... sensations, small band ... paraparesis (mixed UMN
Amyotrophic Lateral Sclerosis (ALS) Summary ALS: combination of the clinical examination finding of amyotrophy with the pathologic
involving both UMN ... multiple spinal cord ... combination of UMN ... combination of UMN ... conditions listed in differential
Generalized Weakness - Differential Diagnosis Framework "l feel weak": • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis •
Generalized Weakness - Differential ... : CHF, valves, COPD ... Infection • Neuro: UMN ... stroke, tumor), LMN ... Generalized #Weakness #Differential
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Severe - ALT >15X ULN ... kwburak #LFTs #Elevated ... #Abnormal #Transaminitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... Severe ALT > 15x ULN ... disease US — Normal ... #LiverEnzymes #Differential
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
- Differential ... injury • Gait is abnormal ... dysfunction • Abnormal ... : Areflexia UMN ... plantar response LMN
Hypercalcemia Evaluation 1) Clinical clues - Is the patient symptomatic? - Family history? - Have you done
likely - Mid range/ULN ... FeCa <1 %) - Low normal ... • If all normal ... Hypercalcemia #workup #differential ... endocrinology #calcium #elevated
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Weakness - Differential ... of the spinal cord ... Gravis - Lack of UMN ... /LMN signs - Lack ... #Weakness #Differential
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
IgG typically elevated ... upper limit of normal ... ALT + AST > 10x ULN ... ALT + AST > 5x ULN ... AND IgG > 2x ULN
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