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Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
Heparin Induced ... ♀, ↑Age, ESRD Pathophysiology ... : Confirmatory test ... D/c all heparin ... #Hematology #HemeOnc
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
- Differential Diagnosis ... considered in all ... Hyperhomocysteinemia - Heparin-induced ... Venous #Arterial #pathophysiology ... #hematology #differential
Vasospastic (Prinzmetal) Angina
Definition / Epidemiology:
 • Rest angina attributed to coronary artery vasospasm.
 • Patients often
younger than other ACS ... Pathophysiology: ... • Imbalance of ... perform provocative tests ... #management
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Incidence: common in APL ... ATRA treatment Pathophysiology ... endothelial damage • Induce ... opacities • Diagnosis ... #management #hematology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... have fever - ACS ... WBC >100k, + lab signs ... Syndrome #TLS #diagnosis ... #management #hematology
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. 

Step 1: In the patient with
regarding the diagnosis ... initial screening test ... Step 3: All patients ... elevated iron indices ... #management #hepatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Increased thrombin ... protein C and S Pathophysiology ... #Coagulation #diagnosis ... causes #treatment #management ... #hematology
Ascites - Diagnosis and Management Summary
Paracentesis studies: cell count + differential, albumin, protein, culture
 • Serum-ascites-albumin-gradient
Ascites - Diagnosis ... and Management ... (maintains K+ balance ... avoid: NSAIDs, ACE ... #Hepatology #SAAG
Anorexia Nervosa: Complications
CARDIAC ABNORMALITIES
 - Functional: Low BP, Sinus bradycardia, prolonged QT interval
 - Structural: Reduced
- Structural: Reduced ... and memory loss HEMATOLOGIC ... mortality rates of all ... Complications #pathophysiology ... #diagnosis #signs