43 results
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... • Aplastic Anemia ... • Anemia of Chronic ... Non-lmmune #Anemia ... #Classification
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... Poisoning • Anemia ... Marrow Failure • Anemia ... Myelodysplasia #Anemia ... #MCV #Classification
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Causes of Anemia ... Normal Blood Smear ... • Pernicious Anemia ... • Pernicious Anemia ... #Macrocytic #Anemia
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
Framework for Anemia ... thalassemia • Anemia ... Normocytic" • Anemia ... Myelodysplastic syndrome ... differential #diagnosis #causes
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... Peripheral blood smear ... DAT (-) → G6PD Deficiency ... → Sickle Cell anemia ... Microangiopathic hemolytic anemia
Gastrointestinal Causes of Iron Deficiency Anemia
 • Mass lesions: Carcinoma, Large polyps
 • Inflammatory: Reflux esophagitis,
Gastrointestinal Causes ... of Iron Deficiency ... Anemia • Mass ... rubber bleb nevus syndrome ... #Anemia #Causes
Causes of Iron Deficiency
 • Inadequate Intake: Vegetarian/vegan diet, Malnutrition
 • Increased Body Needs: Infants/preschoolers, Pregnancy,
Causes of Iron Deficiency ... Pregnancy, EPO treatment ... Loss (without anaemia ... Edema, Celiac disease ... • Inflammatory Disease
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... Microangiopathic hemolytic anemia ... ) - HELLP syndrome ... G6PD deficiency) ... diagnosis #hematology #anemia
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
blood cell count (anemia ... • Anemia • Aplastic ... Anemia • Bone ... Megaloblastic Anemia ... Myelophthisic Anemia
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
secondary to Systemic Diseases ... Spoon-shaped • Iron deficiency ... anemia Onycholysis ... • Nephrotic syndrome ... Diagnosis #Algorithm #causes