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diagnosis differential management neurology autoimmune erythematosus lupus pathophysiology sle systemic vasculitis acute autoantibodies classification complications endocrinology hyperthyroid hyperthyroidism hypothyroid hypothyroidism
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
less systemic symptoms ... heliotrope rash, Shaw sign ... , holster sign, ... , and arthritis ... see mechanics hands
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
- Arthralgia, Arthritis ... Normal CK - Myositis ... Erythematosus #SLE #MSK ... pathophysiology #signs ... #symptoms #diagnosis
Multiple Sclerosis - Summary Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
Examination: • UMN signs ... Clonus, Babinski’s sign ... • Lhermitte’s sign ... pupillary defect SIGNS ... Signs and symptoms
Hypothyroidism and Hyperthyroidism - Symptoms and Signs Hypothyroidism: - General - From asymptomatic to myxedema coma, “Like
Hyperthyroidism - Symptoms ... and Signs Hypothyroidism ... Dermatopathy Ø Hands ... Amy Chung, MD, MSc ... #Signs #Diagnosis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Manifestations: - Arthritis ... anemia 4% - Myositis ... autoantibodies #signs ... #symptoms #mimickers ... #differential #rheumatology
Rheumatoid Arthritis Summary Overview: chronic, inflammatory symmetric polyarthritis involving small joints of hands/feet, knees, shoulders Signs & Symptoms:
Rheumatoid Arthritis ... small joints of hands ... knees, shoulders Signs ... & Symptoms: • ... diagnosis #management #rheumatology
Acute Spinal Cord Injuries: Pathogenesis and clinical findings • Anterior Cord Syndrome -> Anterior spinal artery
: Pathogenesis and ... clumsiness in hands ... rectal reflex. ... pathophysiology #signs ... #symptoms #msk
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
noninflammatory Signs ... constitutional symptoms ... - Autoimmune Rheumatologic ... Differential #Diagnosis #MSK ... #rheumatology #
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
10-33% develop MS ... Spasticity - Reflexes ... • Bilateral signs ... and/or symptoms ... Oligoclonal IgG bands
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... purpura: Strong sign ... • Progressive symptoms ... occasional oligoclonal bands ... Differential #Diagnosis #Rheumatology
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