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diagnosis differential neurology autoimmune management pathophysiology sclerosis spinalcord acute algorithm cord diffuse disorders endocrinology hyperthyroid hyperthyroidism hypothyroid hypothyroidism injury ms
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
less systemic symptoms ... heliotrope rash, Shaw sign ... , holster sign, ... see mechanics hands ... #diagnosis #rheumatology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
skin thickening Signs ... and Symptoms: ... acro-osteolysis, myositis ... #SSc #rheumatology ... #diagnosis #signs
Multiple Sclerosis - Summary Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
Examination: • UMN signs ... Clonus, Babinski’s sign ... • Lhermitte’s sign ... pupillary defect SIGNS ... Signs and symptoms
Hypothyroidism and Hyperthyroidism - Symptoms and Signs Hypothyroidism: - General - From asymptomatic to myxedema coma, “Like
Hyperthyroidism - Symptoms ... and Signs Hypothyroidism ... Dermatopathy Ø Hands ... Amy Chung, MD, MSc ... #Signs #Diagnosis
Acute Spinal Cord Injuries: Pathogenesis and clinical findings • Anterior Cord Syndrome -> Anterior spinal artery
: Pathogenesis and ... clumsiness in hands ... rectal reflex. ... pathophysiology #signs ... #symptoms #msk
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
10-33% develop MS ... Spasticity - Reflexes ... • Bilateral signs ... and/or symptoms ... Oligoclonal IgG bands
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
findings: • Symptoms ... and signs below ... - Transverse myelitis ... disease - SLE, Scleroderma ... dysfunction • Abnormal reflexes
Diffuse Systemic Sclerosis (Scleroderma) - Pulmonary Fibrosis -> Crackles, Abnormal CXR - Pulmonary Hypertension, Right Heart
esophageal dilation, reflux ... Renal Failure - Mask ... fingers) - Finger/hand ... pathophysiology #signs ... #symptoms #diagnosis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... purpura: Strong sign ... • Progressive symptoms ... occasional oligoclonal bands ... Differential #Diagnosis #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... Gottron sign) ... • Shawl sign • ... • Mechanic's hands ... #Myopathy #rheumatology
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