29 results
Colchicine Toxicity 
Naturally-occurring plant alkaloid [Autumn Crocus and Glory Lilly]
2-24 hrs 
 • Severe GI distress
Colchicine Toxicity ... Renal failure • Metabolic ... #Colchicine #Toxicity ... Toxicology #Symptoms #Signs
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Salicylate Toxicity ... show anion-gap metabolic ... Labs: Anion-Gap Metabolic ... Salicylate #Aspirin #Toxicity ... diagnosis #management #Treatment
Tramadol - Toxicology
Due to different CYP-2D6 genotypes, people variably metabolize tramadol into its active metabolite, M1
This
people variably metabolize ... into its active metabolite ... codeine ultra-rapid metabolism ... activity as the M1 metabolite ... in poor codeine metabolism
Antifungal Azoles - Antibiotics Class Overview

Mechanism:  inhibit ergosterol synthesis (important component of fungal cell membranes)
membranes) - Main metabolism ... hepatic, main toxicity ... Isavuconazole(PO or IV) #Pharmacology
Clozapine Toxicology
Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
patients who have treatment-resistant ... following first-pass metabolism ... - Metabolism - ... #Toxicology #Toxicity ... #Diagnosis #Pharmacology
Propofol-Related Infusion Syndrome (PRIS)

Diagnosis is based on a constellation of clinical suspicion and biochemical signs including:
and biochemical signs ... Hyperlactatemia • Metabolic ... Diagnosis #Management #Pharmacology ... #Toxicity #Toxicology
Risk Factors and Signs of Copper Deficiency
Risk Factors:
 • Gastrointestinal: Previous upper bowel resection/bariatric surgery, Inflammatory
Risk Factors and Signs ... dental fixatives, Treatment ... Wilson's disease • Metabolic ... , Malnutrition Signs ... Deficiency #diagnosis #signs
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Radiation • Metabolic ... Organophosphate toxicity ... - Carbamate toxicity ... Lack of UMN/LMN signs ... Hypothyroid • Metabolic
HIV Antiretroviral Pharmacokinetic Boosters - Ritonavir & Cobicistat 

Ritonavir & Cobicistat are 2 pharmacokinetic boosters used
boosters used in HIV treatment ... they lower the metabolism ... HIV #Boosters #Pharmacology
DKA DIAGNOSTIC CRITERIA:
1. Serum glucose >250 mg/dL
2. Arterial pH <7.3
3. Serum bicarbonate <18 mEq/L
4. At least
significant anion gap metabolic ... Common, early signs ... production, the rate of metabolism ... Treatment with IV