79 results
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... can indicate disease ... microglobulin Treatment ... • Richter’s Syndrome ... leukemia • Sezary syndrome
Castleman's Disease and Associated Syndromes
HYALINE VASCULAR VARIANT
 • unicentric, HHV8-ve, children and young.
 • Hyalinized vessels
Castleman's Disease ... and Associated Syndromes ... fashion- onion skin ... Pathogenesis "IL6 syndrome ... " Plasma cell
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... Myeloproliferative Disease ... factor (GCSF) treatments ... marrow studies Treatment ... Immunosuppressive treatment
Ulcerative Blastomycosis Skin Lesion
57 asymptomatic M from Indiana nonpruritic, painless, progressive skin lesion lower back x
Blastomycosis Skin ... differential: basal ... cell ca, squamous ... cell ca, pyoderma ... University Infectious Diseases
Eosinophilia - Differential Diagnosis Algorithm
Idiopathic Eosinophilia
Primary Eosinophilia:
 • Primary hypereosinophilic syndrome
 • Eosinophilic Leukemia
 • MPN/MDS
GI, lung, skin), ... malig (AML, CML, T-cell ... leuk/lymphoma, B-cell ... AI: EGPA, IgG-4 disease ... , Behcet disease
Hansen's Disease (Leprosy)
 • Transmission - not completely understood, ?nasal droplets
 • Symptoms appear ~5 years
nasal droplets ... & SC fat with well-defined ... cytoplasm, plasma cells ... and numerous AFB Treatment ... diagnosis #management #treatment
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Polyangiitis (GPA) Skin ... GPA causes disease ... joints • Oral and nasal ... • Goodpasture syndrome ... • Giant cell arteritis
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
response to local skin ... spinal cord, and basal ... retinal damage) • Skin ... test (this is a skin ... Arthritis, AS Treatment
BEE Syndromes - Non-inflammatory Causes

Immune-mediated conditions affecting the Brain, Eye, and Ear

Visual or auditory symptoms in
and less common diseases ... diagnosis and treatment ... infections • Lyme disease ... neoplasms (e.g., nasal ... squamous cell carcinoma
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
nose chondritis, skin ... thromboembolic disease ... (12%) • giant cell ... hematopoietic stem cells ... blood myeloid cells