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Diffuse large B cell lymphoma (DLBCL) - Management and Treatment Algorithm

By Matthew Ho, MD PhD @MatthewHoMD

#Diffuse
Diffuse large B cell ... Diffuse #large #Bcell ... Treatment #Algorithm #oncology
Aplastic Anemia Summary

 • Definition
 • Pathophysiology
 • DDx: AA vs Hypocellular MDS
 • Expectation
 •
Definition • Pathophysiology ... Anemia #diagnosis #oncology
Lymphoma Classification
Non-Hodgkin - T-Cell Lymphoma
Non-Hodgkin - B-Cell Lymphomas:
 • Highly Aggressive - Burkitt, Aggresive
 • Aggressive
Non-Hodgkin - T-Cell ... Non-Hodgkin - B-Cell ... DLBCL, Mantle Cell ... Classification #oncology
Tumor markers in clinical practice
Colorectal - CEA
Hepatocellular - AFP
Pancreatic - CA 19-9
Ovarian - CA 125
Breast -
Prostate - PSA Germ cell ... Lung (non-small cell ... SCC Lung (small cell ... laboratory #diagnosis #oncology
Sickle Cell Vaso-Occlusive Crisis

#SickleCell #Crisis #Vasoocclusive #AcuteChestSyndrome #ACS #Pathophysiology #Hematology
Sickle Cell Vaso-Occlusive ... AcuteChestSyndrome #ACS #Pathophysiology
Gastric Acid Secretion - Pathophysiology
Chief cell - Pepsinogen
Parietal cell - Acid, Intrinsic factor
G cell - Gastrin
Inhibitors:
Acid Secretion - Pathophysiology ... Chief cell - Pepsinogen ... Parietal cell - ... Intrinsic factor G cell ... Acid #Secretion #Pathophysiology
Oncologic Emergencies - Differential Diagnosis Framework

HEMATOLOGIC ONCOLOGIC EMERGENCIES:
Hyperviscosity Syndrome:
 • Spontaneous bleeding
 • Shortness of breath
Oncologic Emergencies ... HEMATOLOGIC ONCOLOGIC ... STRUCTURAL ONCOLOGIC ... ) METABOLIC ONCOLOGIC ... #emergencies #oncology
Hypercalcemia of Malignancy - Pathophysiology
PTH-mediated
 • Parathyroid cancer
 • Ectopic production: Small cell lung cancer, ovarian
of Malignancy - Pathophysiology ... production: Small cell ... bone • Squamous Cell ... of lung, Renal Cell ... Hypercalcemia #Malignancy #Pathophysiology
Infection-Related Cancers
Viruses:
 • HPV - Cervical, anogenital, head and neck, skin cancer
 • HTLV-1 - Adult
HTLV-1 - Adult T-cell ... sarcoma, Merkel cell ... cancer • Merkel cell ... polyomavirus - Merkel cell ... Associations #Cancers #oncology
Melanoma Pathogenesis

Environmental exposure (UV light) + genetic susceptibility (CDKN2A, CDK4, MC1R, BRAF, p16/ARF genes) → accumulation
#Pathophysiology ... #Oncology #Melanoma